| CASE SERIES |
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| Year : 2022 | Volume
: 1
| Issue : 2 | Page : 121-126 |
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Obesity as a trigger for autoimmune rheumatic diseases: Case series
HR Hemanth Kumar, Meenakshi Kalyan, Aditya Vedula, Chaitra Kolli, Sania Saba, Shashank Dharma
Department of Medicine, Vydehi Institute of Medical Science and Research Centre, Bengaluru, Karnataka, India
Correspondence Address:
Meenakshi Kalyan
Department of Medicine, Vydehi Institute of Medical Science and Research Centre, Whitefield, Bengaluru - 560 066, Karnataka
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/cdrp.cdrp_3_22
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The chronic low-grade inflammation in obesity and multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of various rheumatic autoimmune and inflammatory conditions. Obesity is a low-grade systemic inflammatory condition with elevated levels of inflammatory markers such as leptin, C-reactive protein, tumor necrosis factor-α, and interleukin-6. Dysregulation of the cytokines and adipokines is a feature of metabolic syndrome, suggesting a complex relationship between autoimmunity, obesity, and atherosclerosis. We discuss the effects of obesity and its association with newly diagnosed immune-mediated disorders such as Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, and antiphospholipid antibody syndrome in a case series of eight patients.
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