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Year : 2022  |  Volume : 1  |  Issue : 2  |  Page : 121-126

Obesity as a trigger for autoimmune rheumatic diseases: Case series

Department of Medicine, Vydehi Institute of Medical Science and Research Centre, Bengaluru, Karnataka, India

Correspondence Address:
Meenakshi Kalyan
Department of Medicine, Vydehi Institute of Medical Science and Research Centre, Whitefield, Bengaluru - 560 066, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cdrp.cdrp_3_22

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The chronic low-grade inflammation in obesity and multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of various rheumatic autoimmune and inflammatory conditions. Obesity is a low-grade systemic inflammatory condition with elevated levels of inflammatory markers such as leptin, C-reactive protein, tumor necrosis factor-α, and interleukin-6. Dysregulation of the cytokines and adipokines is a feature of metabolic syndrome, suggesting a complex relationship between autoimmunity, obesity, and atherosclerosis. We discuss the effects of obesity and its association with newly diagnosed immune-mediated disorders such as Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, and antiphospholipid antibody syndrome in a case series of eight patients.

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